Key words: Liver cirrhosis Gut motility Gastric accommodation Malnutrition Gastrointestinal symptoms Intestinal permeability Core tip: Features of gut dysfunction are common in patients with cirrhosis and may have an impact on quality of life and nutritional status as well as contribute to the development of cirrhosis complications. WJG|toxin and bacterial DNA, thus potentially being involved in the pathogenesis of complications of liver cirrhosis. Finally, several studies have reported intestinal barrier dysfunction in patients with cirrhosis (especially those with portal hypertension), which is related to bacterial translocation and permeation of intestinal bacterial products, e.g. Furthermore, small bowel manometry disturbances and delayed gut transit may be associated with the development of small bowel bacterial overgrowth. This may be related to disturbances in postprandial glucose, insulin, and ghrelin levels, which, in turn, appear to be associated to insulin resistance, a common finding in cirrhosis. Gastric emptying and small bowel transit have generally been shown to be prolonged. Although tense ascites appears to have a negative impact on meal-induced accommodation of the stomach, published data on gastric accommodation in cirrhotics without significant ascites are not unanimous. They may lead to reduced food intake and, thus, may contribute to the nutritional status deterioration in cirrhotic patients. , increased gastric sensitivity to distension and delayed gut transit). Gastrointestinal symptoms are common in cirrhosis and their pathophysiology probably involves factors related to liver disease severity, psychological distress, and gut dysfunction (e.g. Telephone: +46-46-171000 Fax: +46-46-2110908 Received: OctoRevised: ApAccepted: JPublished online: October 28, 2014Ībstract Patients with liver cirrhosis exhibit several features of gut dysfunction which may contribute to the development of cirrhosis complications as well as have an impact on nutritional status and health-related quality of life. Correspondence to: Evangelos Kalaitzakis, MD, PhD, FEBGH, Associate Professor, Department of Gastroenterology, Skåne University Hospital, University of Lund, 22185 Lund, Sweden. Gastrointestinal dysfunction in liver cirrhosis Evangelos Kalaitzakis Evangelos Kalaitzakis, Department of Gastroenterology, Skåne University Hospital, University of Lund, 22185 Lund, Sweden Author contributions: Kalaitzakis E solely contributed to this paper.  TOPIC HIGHLIGHT WJG 20th Anniversary Special Issues (11): Cirrhosis

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